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Relationships between weight and BMI and efavirenz daily concentrations or etravirine plasma exposure (expressed as the ratio between AUC before and after 14-day efavirenz intake period) were assessed by Pearson correlation (the groups were separated into halves by median weight and BMI)

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At present, there is no reliable marker of hepatic drug-metabolizing function that can be used to predict changes in liver clearance in a manner analogous to the use of creatinine clearance as a marker of renal drug clearance